- Selected Publications
- Team Members
- Curriculum Vitae
Thomas M. Hyde, M.D., Ph.D. is the Chief Medical Officer at the Institute. Dr. Hyde is also the Director of the Section on Neuropathology, managing the Institute’s postmortem human brain repository. This repository, containing over 2000 cases and growing, is the world’s largest collection of human brains dedicated to the study of neuropsychiatric disorders. He is an Associate Professor in the Departments of Neurology and Psychiatry & Behavioral Sciences at the Johns Hopkins School of Medicine. Dr. Hyde is also on the board of directors for the Sheppard-Pratt Lieber Research Institute, a clinical research center focused on understanding the biology of schizophrenia, autism, and other developmental neuropsychiatric disorders.
Dr. Hyde researches GABA signaling across the stages of normal development and in major psychiatric diseases. He has co-authored more than 190 peer-reviewed research publications, with a focus on the postmortem human brain and complex developmental behavioral disorders. He attended the University of Pennsylvania, receiving a B.A. in Biology in 1978, graduating summa cum laude. He received a joint M.D.-Ph.D. in 1984, with a Ph.D. from the Department of Anatomy. While at Penn, he was the recipient of a University Scholars Award, and an NIH Medical Scientist Training Program Scholarship. He served a general medical internship at the Penn Presbyterian Medical Center from 1984-1985, followed by a neurology residency at Stanford University from 1985-1988. He served as Chief Resident in Neurology the final year of his residency. After leaving California, Dr. Hyde worked in the Clinical Brain Disorders Branch (CBDB) of the intramural program of the National Institute of Mental Health (NIMH). He ran the Neurology Consultation Clinics at St. Elizabeth’s Hospital under the auspices of the NIMH from 1988-1996.
From 1996-2010, he worked full-time in the Section on Neuropathology in the CBDB, developing an extensive collection of postmortem human brains dedicated to neuropsychiatric disease in general, and schizophrenia in particular. At the Lieber Institute, he has continued and expanded upon this effort, establishing one of the world’s largest and most extensively curated brain tissue collections for research. Under his supervision and leadership, the Lieber Institute has established brain donation collection sites in collaboration with the Office of the Chief Medical Examiner for the State of Maryland, the University of Western Michigan Department of Pathology, and the University of Sofia in Sofia, Bulgaria.
Bliss LA, Sams MR, Deep-Soboslay A, Ren-Patterson R, Jaffe A, Chenoweth JG, Jaishankar A, Kleinman, JE, Hyde TM. Use of Postmortem Human Dura Mater and Scalp for Deriving Human Fibroblast Cultures. PloS One. 7(9):e45282, 2012.
Tao R, C Li, Newburn EN, Ye T, Lipska, BK, Herman MM, Weinberger DR, Kleinman JE, Hyde TM. Transcript-Specific Associations of SLC12A5 (KCC2) in Human Prefrontal Cortex with Development, Schizophrenia, and Affective Disorders. Journal of Neuroscience. 32:5216-5222, 2012.
Colantuoni C, Lipska BK,, Ye T, Hyde TM, Tao R, Leek, JE, Colantuoni EA, Elkahloun AG, Herman MM, Weinberger DR, Kleinman JE. Temporal Dynamics and Genetic Control of Transcription in the Human Prefrontal Cortex. Nature. 478:519-523, 2011.
Numata, S, Ye T, Hyde TM, Guitart-Navarro X, Tao R, Wininger M, Colantuoni C, Weinberger DR, Kleinman JE, Lipska BK. DNA Methylation Signatures in Development and Aging of the Human Prefrontal Cortex. American Journal of Human Genetics. 90:260-272, 2012.
Ye T, Lipska BK, Tao R, Hyde TM, Wang L, Li C, Choi KH, Straub RE, Kleinman JE, Weinberger D. Analysis of Copy Number Variations in Brain DNA From Patients with Schizophrenia and Other Psychiatric Disorders. Biological Psychiatry. 72:651-4, 2012.
Kunii Y, Hyde TM, Li C, Kolachana B, Dickinson D, Weinberger DR, Kleinman JE, Lipska BK. Revisiting DARPP-32 in Postmortem Human Brain: Changes in Schizophrenia and Bipolar Disorder and Genetic Associations with t-DARPP-32 Expression. Molecular Psychiatry. 19(2):192-9, 2014.
Rahul Bharadwaj, Ph.D. manages human post-mortem brain processing and edits the neuropathology reports on every case donated through the State of Maryland Office of the Chief Medical Examiner. He has processed over 600 postmortem brains for the LIBD Human Brain Repository. His research skill set include epigenetic modifications of DNA and laser capture micro dissection (LCM), which he is applying to Alzheimer’s, PTSD and schizophrenia research.
Anna Brandtjen specializes in patient-derived fibroblasts primary cell cultures for the LIBD Human Brain Repository. She also maintains IRB protocols, helps manage the clinical data for the Human Brain Repository, and is a contributing member of the clinical diagnostics team.
Amy Deep-Soboslay is the Manager, Clinical Assessment for the Neuropathology Division. She is primarily responsible for conducting postmortem diagnostic evaluations in the LIBD Human Brain Repository, with retrospective psychiatric record reviews and/or family informant interviews, in order to determine lifetime psychiatric diagnoses for every brain donor (i.e., over 1,000 individuals and counting).
Chao Li, Ph.D. is working as the Laboratory Information Management System (LIMS) Administrator on the Neuropathology team. She customizes the LIMS to fulfill the needs of the Section, writing code to augment the system as needed. She also maintains, tracks, and manages quality control of DNA, RNA, and protein extracts from postmortem human brain.
Michelle Mighdoll is the Director of Lieber West, where she manages the upcoming brain collection work with the Office of the Chief Medical Examiner for Santa Clara County, California. In addition to both the careful physical and clinical curation of brains, she is working to expand Lieber’s strategic business partnerships on the West Coast with a focus on the Bay Area. Prior to this, Michelle was the manager of the brain collection team in Baltimore.
Taylor Pinckney is a Clinical Project Coordinator and the Liaison with the State of Maryland Office of the Chief Medical Examiner on behalf of the Neuropathology Division. At the Lieber Institute, Taylor is responsible for working with outside physicians, clinics, and hospitals to acquire medical records pertaining to each case to allow accurate retrospective diagnoses.
Ran Tao, Ph.D. oversees and manages the postmortem human brain tissue samples and LIMS for nucleic acid sample preparation and other downstream molecular biology experiments. He also has been studying mechanisms of risk from genetic variants associated with schizophrenia and other psychiatric disorders in human postmortem brain tissue, focusing on abnormalities in GABA signaling and schizophrenia.
Yoichiro Takahashi, Ph.D. is a visiting Research Fellow from Japan, and a specialist in forensic medicine, whose interest is in the postmortem evaluation of neuropsychiatric diseases. He is studying transcriptome analysis of single cells using postmortem human brains, to elucidate the molecular mechanisms underlying schizophrenia.
James Tooke is a Research Associate and manages a variety of aspects in brain tissue processing, inventory organization, and human brain tissue dissections. He is currently working with Dr. Rahul Bharadwaj to develop projects related to schizophrenia, dopamine, and aging, using laser capture microdissection.
James Weiss is a Research Assistant in the Neuropathology Division.
Rae’e Yamin is a research technician for the Neuropathology Section. He works with Drs. Li and Tao, performing the DNA and RNA extractions on the human brain samples at the Institute. He also helps in organizing and cataloging those extractions for future use.