Thomas M.
Hyde, M.D., Ph.D.
About
Thomas M. Hyde, M.D., Ph.D. is the Chief Medical Officer at the Institute. Dr. Hyde is also the Director of the Section on Neuropathology, managing the Institute's postmortem human brain repository. This repository, containing over 2000 cases and growing, is the world’s largest collection of human brains dedicated to the study of neuropsychiatric disorders. He is an Associate Professor in the Departments of Neurology and Psychiatry & Behavioral Sciences at the Johns Hopkins School of Medicine. Dr. Hyde is also on the board of directors for the Sheppard-Pratt Lieber Research Institute, a clinical research center focused on understanding the biology of schizophrenia, autism, and other developmental neuropsychiatric disorders. Dr. Hyde researches GABA signaling across the stages of normal development and in major psychiatric diseases. He has co-authored more than 190 peer-reviewed research publications, with a focus on the postmortem human brain and complex developmental behavioral disorders. He attended the University of Pennsylvania, receiving a B.A. in Biology in 1978, graduating summa cum laude. He received a joint M.D.-Ph.D. in 1984, with a Ph.D. from the Department of Anatomy. While at Penn, he was the recipient of a University Scholars Award, and an NIH Medical Scientist Training Program Scholarship. He served a general medical internship at the Penn Presbyterian Medical Center from 1984-1985, followed by a neurology residency at Stanford University from 1985-1988. He served as Chief Resident in Neurology the final year of his residency. After leaving California, Dr. Hyde worked in the Clinical Brain Disorders Branch (CBDB) of the intramural program of the National Institute of Mental Health (NIMH). He ran the Neurology Consultation Clinics at St. Elizabeth's Hospital under the auspices of the NIMH from 1988-1996. From 1996-2010, he worked full-time in the Section on Neuropathology in the CBDB, developing an extensive collection of postmortem human brains dedicated to neuropsychiatric disease in general, and schizophrenia in particular. At the Lieber Institute, he has continued and expanded upon this effort, establishing one of the world’s largest and most extensively curated brain tissue collections for research. Under his supervision and leadership, the Lieber Institute has established brain donation collection sites in collaboration with the Office of the Chief Medical Examiner for the State of Maryland, the University of Western Michigan Department of Pathology, and the University of Sofia in Sofia, Bulgaria.
Selected publications
Bliss LA, Sams MR, Deep-Soboslay A, Ren-Patterson R, Jaffe A, Chenoweth JG, Jaishankar A, Kleinman, JE, Hyde TM. Use of Postmortem Human Dura Mater and Scalp for Deriving Human Fibroblast Cultures. PloS One. 7(9):e45282, 2012. Tao R, C Li, Newburn EN, Ye T, Lipska, BK, Herman MM, Weinberger DR, Kleinman JE, Hyde TM. Transcript-Specific Associations of SLC12A5 (KCC2) in Human Prefrontal Cortex with Development, Schizophrenia, and Affective Disorders. Journal of Neuroscience. 32:5216-5222, 2012. Colantuoni C, Lipska BK,, Ye T, Hyde TM, Tao R, Leek, JE, Colantuoni EA, Elkahloun AG, Herman MM, Weinberger DR, Kleinman JE. Temporal Dynamics and Genetic Control of Transcription in the Human Prefrontal Cortex. Nature. 478:519-523, 2011. Numata, S, Ye T, Hyde TM, Guitart-Navarro X, Tao R, Wininger M, Colantuoni C, Weinberger DR, Kleinman JE, Lipska BK. DNA Methylation Signatures in Development and Aging of the Human Prefrontal Cortex. American Journal of Human Genetics. 90:260-272, 2012. Ye T, Lipska BK, Tao R, Hyde TM, Wang L, Li C, Choi KH, Straub RE, Kleinman JE, Weinberger D. Analysis of Copy Number Variations in Brain DNA From Patients with Schizophrenia and Other Psychiatric Disorders. Biological Psychiatry. 72:651-4, 2012. Kunii Y, Hyde TM, Li C, Kolachana B, Dickinson D, Weinberger DR, Kleinman JE, Lipska BK. Revisiting DARPP-32 in Postmortem Human Brain: Changes in Schizophrenia and Bipolar Disorder and Genetic Associations with t-DARPP-32 Expression. Molecular Psychiatry. 19(2):192-9, 2014.
Curriculum vitae
Download a PDF copy of my CV here: Hyde_CV_LIBD