- Selected Publications
Keri Martinowich, Ph.D. is a Lead Investigator in the Brain Development division of the Lieber Institute. Her research focuses on the roles of brain-derived neurotrophic factor (BDNF) signaling and neurogenesis in normal neurodevelopment and in the context of neuropsychiatric disorders. In particular, she is interested in understanding how neuronal activity contributes to the function of cortical circuits that mediate complex brain function and behavior, and in the role of transcript-specific regulation of the BDNF gene. Dr. Martinowich received a B.A. in International Relations from George Washington University and a Ph.D. in Neuroscience at the University of California, Los Angeles (UCLA). While at UCLA, she received a National Research Service Award from the National Institute of Neurological Disorders and Stroke, as well as predoctoral training grants from the Medical Investigation of Neurodevelopmental Disorders Institute and the UCLA Mental Retardation Research Center. After leaving UCLA, Dr. Martinowich completed postdoctoral work in the intramural program of the National Institute of Mental Health (NIMH) as a joint fellow in the Mood and Anxiety Disorders Program and the Genes, Cognition and Psychosis Program. During this time she was the recipient of a National Association for Research on Schizophrenia and Depression Young Investigator Award as well as the Richard J. Wyatt NIMH Fellowship Award.
Martinowich K, Schloesser RJ, Lu Y, Jimenez DV, Paredes D, Greene JS, Greig NH, Manji HK, Lu B. Roles of p75NTR, Long-Term Depression and Cholinergic Transmission in Anxiety and Acute Stress Coping, Biological Psychiatry 2011; 71(1), 75-83.
Martinowich K, Schloesser RJ, Jimenez DV, Weinberger DR, Lu B. Activity-Dependent Brain-Derived Neurotrophic Factor Expression Regulates Cortistatin-Interneurons and Sleep Behavior. Molecular Brain 2011; 4(11).
Sakata K,Woo N, Martinowich K, Greene JS, Schloesser RJ, Shen L, Lu B. Critical Role of Promoter-IV-Driven BDNF Transcription in GABAergic Transmission and Synaptic Plasticity in the Prefrontal Cortex. PNAS 2009; 106(14), 5942-5947.
Martinowich K, Manji HK, Lu B, New Insights into BDNF Function in Depression and Anxiety. Nature Neuroscience 2007; 10(9), 1089-1093.
Martinowich K, Hattori D, Wu H, Fouse S, He F, Hu Y, Fan G, Sun YE. DNA Methylation-Related Chromatin Remodeling in Activity-Dependent BDNF Gene Regulation. Science 2003; 302(5646), 890-893.