James-Barrow-PhD

About

Dr. James Barrow is a Professor of Pharmacology at Johns Hopkins University and Senior Investigator and Director of the Drug Discovery Division at the Lieber Institute. Dr. Barrow has 14 years of industrial experience in drug discovery research at Merck Research Laboratories and held many leadership roles before coming to the Lieber Institute in 2010. He has published over 70 peer-reviewed articles, reviews, and book chapters dealing with organic synthesis and drug discovery, most for central nervous system disorders, as well as 36 issued patents. He was part of development teams at Merck that brought new chemical entities through toxicology studies and into Phase 1 and 2 clinical trials. At the Lieber Institute, he has continued to lead drug discovery teams looking for treatments of psychiatric disorders, resulting in several programs out-licensed to biopharmaceutical companies. Dr. Barrow received a B.S. in chemistry from the University of North Carolina, Chapel Hill, graduating with highest honors and highest distinction. He received his Ph.D. from Harvard University, working in the laboratory of Professor David A. Evans.

Selected Publications

Carr GV, Chen J, Yang F, Ren M, Yuan P, Tian Q, Bebensee A, Zhang GY, Du J, Glineburg P, Xun, R, Akhile, O, Pickel, J, Barrow, JC, Papaleo, F, Weinberger, DR. KCNH2-3.1 expression impairs cognition and alters neuronal function in a model of molecular pathology associated with schizophrenia. Mol Psychiat. 2016; 21: 1517.

Team Members