Alan Lorenzetti is a Postdoctoral Fellow working in the laboratories of Dr. Apuã Paquola and Dr. Jennifer Erwin. He joined the Lieber Institute in late 2022. His work mostly focuses on the characterization of repetitive sequences, such as transposable elements, using DNA and RNA long-read sequencing technologies (e.g., Nanopore and PacBio).
He earned a master’s degree in Genetics and Molecular Biology from the State University of Londrina (2016; Londrina, Paraná, Brazil) and a Ph.D. in Bioinformatics from the University of São Paulo (2021; Ribeirão Preto, São Paulo, Brazil). He has been working in bioinformatics for omics since his undergraduate studies, when he realized the data analysis skillset could leverage the investigation of molecular traits in any living being.
He has contributed to the field of i) plant genomics/transcriptomics, by determining the colocalization of transposable elements and microRNA precursor loci and by establishing reference transcriptomes; ii) bacterial gene expression, by helping with characterizing the stress response to iron deficiency, oxidative stress, and low temperatures (Caulobacter crescentus) and with describing components of the type-VI secretion system in a plant pathogen (Xanthomonas citri); iii) archaeal gene expression, by assessing the system-wide post-transcriptional regulation landscape of the extreme halophile Halobacterium salinarum using multi-omics techniques.
Now, at the LIBD, he is once more exploring a new field to apply his skillset and seeks to contribute to a better understanding of brain development.