Solomon Snyder, M.D.

About

Solomon Snyder, M.D. is the Distinguished Service Professor of Neuroscience, Pharmacology and Psychiatry at the Johns Hopkins University School of Medicine. Dr. Snyder received his undergraduate and medical training at Georgetown University and joined the faculty of the Johns Hopkins University School of Medicine. In 1980 he established the Department of Neuroscience and served as Director (1980-2006). He is the author of more than 1000 journal articles and several books. Dr. Snyder also served as founder and chair of the Scientific Advisory Board for two biotechnology companies, Nova Pharmaceuticals and, most recently, Guilford Pharmaceuticals, now part of Eisai. His research, honored with the 1978 Lasker Award and 2005 National Medal of Science, has led to many advances in the understanding of molecular neuroscience deriving from his identification of receptors for neurotransmitters and drugs, and from his elucidation of the action of psychotropic agents. Among other findings, he established gases as a new class of neurotransmitters and drugs, including nitric oxide and carbon monoxide and demonstrated the role of nitric oxide in mediating glutamate transmission. He has been a member of the Scientific Council of NARSAD (now the Brain and Behavior Research Foundation) since its inception in 1986 and a member of the National Academy of Sciences. He received the NARSAD Lieber Prize for Outstanding Achievement in Schizophrenia Research in 2001 and its Goldman-Rakic Prize for Outstanding Achievement in Cognitive Neuroscience in 2003.

Selected Publications

Sen N, Paul BD, Gadalla MM, Mustafa AK, Sen T, Xu R, Kim S, Snyder SH. (2012) Hydrogen Sulfide-Linked Sulfhydration of NF-κB Mediates its Antiapoptotic Actions. Mol Cell. 2012 Jan 13;45(1):13-24.

Subramaniam S, Napolitano F, Mealer RG, Kim S, Errico F, Barrow R, Shahani N, Tyagi R, Snyder SH, Usiello A. (2011) Rhes, a Striatal-Enriched Small G Protein, Mediates mTOR Signaling and L-DOPA-Induced Dyskinesia. Nat Neurosci. 2011 Dec 18; 15(2):191-3.

Sen N, Snyder SH. (2011) Neurotrophin-Mediated Degradation of Histone Methyltransferase by S-Nitrosylation Cascade Regulates Neuronal Differentiation. Proc Natl Acad Sci. USA 2011 Dec 13; 108(50):20178-83. Epub 2011 Nov 28.

Chakraborty A, Kim S, Snyder SH. (2011) Inositol Pyrophosphates as Mammalian Cell Signals. Sci Signal 2011 Aug 23; 4(188):re1.

Kim S, Kim SF, Maag D, Maxwell MJ, Resnick AC, Juluri KR, Chakraborty A, Koldobskiy MA, Cha SH, Barrow R, Snowman AM, Snyder SH. (2011) Amino Acid Signaling to mTOR Mediated by Inositol Polyphosphate Multikinase. Cell Metab. 2011 Feb 2; 13(2)215-21

Kornberg MD, Sen N, Hara MR, Juluri KR, Nguyen JV, Snowman AM, Law L, Hester LD, Snyder SH. (2010) GAPDH Mediates Nitrosylation of Nuclear Proteins. Nat Cell Biol. 2010 Nov; 12(11):1094-100. Epub 2010 Oct 24.

Chakraborty A, Koldobskiy MA, Bello NT, Maxwell M, Potter JJ, Juluri KR, Maag D, Kim S, Huang AS, Dailey MJ, Saleh M, Snowman AM, Moran TH, Mezey E, Snyder SH. (2010) Inositol Pyrophosphates Inhibit Akt Signaling, Thereby Regulating Insulin Sensitivity and Weight Gain. Cell 2010 Dec 10; 143(6):897-910.

Mustafa AK, Gadalla MM, Sen N, Kim S, Mu W, Gazi SK, Barrow RK, Yang G, Wang R, Snyder SH. (2009) H2S Signals Through Protein S-sulfydration. Sci Signal 2009 Nov 10; 2(96):ra72.

Subramaniam S, Sixt KM, Barrow R, Snyder SH. (2009) Rhes, a Striatal Specific Protein, Mediates Mutant-huntingtin Cytotoxicity. Science 2009 Jun 5; 324(5932):1327-30. [PDF]

Yang G, Wu L, Jiang B, Yang W, Qi J, Cao K, Meng Q, Mustafa AK, Mu W Zhang S, Snyder SH, Wang R. (2008) H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine Gamma-lyase. Science 2008 Oct 24; 322(5901):587-90.