- Selected Publications
Federica Farinelli, Ph.D joined the Lieber Institute as a staff scientist I in the February 2019.
Her research interest lies at the intersection of quantitative physiology and molecular biophysics employing multiple electrophysiological techniques to study ion channel signaling complexes that are critical to neurological and cardiovascular function. Dr. Farinelli earned her Ph.D. degree in neurobiology and electrophysiology from the University of Ferrara in Italy. Prior to joining the Lieber Institute, Federica worked as a senior postdoc/research associate in Dr. Tomaselli’s lab at Johns Hopkins University School of Medicine. During this time, the focus of her research primarily focused was on sodium channel isoforms, including structures, domain specific functions, and pharmacology mostly in relation to channelopathies providing that provide the biophysical bases for possible therapeutic targets.
Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif. Yoder JB et all .Nat Commun. 2019
NaV Channels: Assaying Biosynthesis, Trafficking, Function.
Tomaselli GF, Farinelli F. Methods Mol Biol. 2018
Regulation of the NaV1.5 cytoplasmic domain by calmodulin.
Gabelli SB et all. Nat Commun. 2014
A mutation causing Brugada syndrome identifies a mechanism for altered autonomic and oxidant regulation of cardiac sodium currents.
Aiba T et all. Circ Cardiovasc Genet. 2014