Lieber LENS
The goal of research at LIBD is to identify new strategies to change the lives of individuals affected by schizophrenia and related developmental disorders.
Immunofluorescence Staining of the Adult Hippocampus for Markers of the Neurovascular Unit
Staining of a neurotypical control donor with MAP2 (magenta) to mark neurons, CLDN5 (green) to mark blood vessels, GFAP (yellow) to mark astrocytes, and IBA1 (red) to mark microglia.
The Rooster of Molecular Variation in the Dorsal Pons
The image on the left is superimposed over an image of a real AI interaction and shows a data-driven, unsupervised 2-D representation of gene expression data collected from several samples of brainstem tissue, with each sample in a unique color.
The resemblance of this completely arbitrary arrangement of data points was so striking that I decided to test what AI interpreted this image to be, if anything. To make the question posed to the AI more challenging, I concealed the answer (UMAP plot) by cropping out the axis labels and changed to a monochrome filter for no particular color. The AI query and response are shown.
Neuromelanin of the Locus Coeruleus
Hematoxylin and eosin staining of the locus coeruleus. Cellular morphology is well preserved allowing for high contrast between the nuclei, nissil substance, axon tracts, and neuromelanin.
Marker gene expression for macaque Marker gene expression for macaque lateral amygdala (LA) and basal amygdala (BA)
2X smFISH images of the basolateral region of the macaque brain illustrating expression of PEX5L (red) in BA and SATB1 (yellow) in LA, SLC1A7 in BLA (magenta). The MBP signal (green) represents white matter for anatomical landmarks.
A Galaxy Inside the Brain
A map of thousands of cells from a human hippocampus. Each dot is a cell detected from fluorescence microscopy and classified by machine learning- a computational view of the very same background image of the contest.
A Stream of Serotonin: The Human Dorsal Raphe Nucleus
20× fluorescence images of the dorsal raphe nucleus (DRN), the largest serotonergic hub in the brain. A river-like stream of TPH2 (pink) and SLC6A4 (yellow) marks the DRN, while DBH (red) highlights the locus coeruleus.
Human Dorsolateral Prefrontal Cortex Layers
Human DLPFC Stained for Nuclei, (blue) Glia (orange), and layer 4 neurons (Magenta). You can nicely see the shift between expression patterns of magenta indicating layers of the cortex.
Major thalamic nuclei
Image shows a section taken from the Anterior thalamus and probed for CCK (purple), GAD1 (Red), ETV1 (yellow), and MBP (Green). The combination of these genes nicely shows the major thalamic nuclei present in the anterior thalamus.
Locus Coeruleus Tau Tango: Astrocytes Guard, Vessels Pulse, pTau Plots
Multiplexed immunofluorescence of human locus coeruleus reveals DAPI nuclei (blue), GFAP astrocytes (green), Claudin-5 blood vessels (red), and pTau phosphorylated Tau pathology (magenta) —neurodegeneration’s vibrant cast.
Mediodorsal nucleus of the thalamus
Image showing the spatial organization of the thalamic nuclei. CCK (purple) marks the interneurons surrounding the mediodorsal (MD) nucleus. ETV1 (yellow) marks the ventral lateral (VL) nucleus of the thalamus. GAD1 (Red) marks entire thalamus.
Habenula Hunt
Anatomic verification of the human habenula via RNAscope. TAC3 – yellow, GPR151 – pink, POU4F1 – red, MBP – green. The structure is only ~1.5mm in width and anywhere from 3-9mm in depth. It has taken over 3 years to identify a cohort of 60.
Between the Nerves
VisiumHD map of the human ventral tegmental area (VTA), showing 8 µm-binned MBP expression in a midbrain section. The VTA lies between diverging oculomotor nerve fibers, resembling a hidden valley between two rivers of myelinated tracts
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