Joyce van de Leemput is a Staff Scientist at the Erwin lab, where she uses a hybrid of human stem cell models and postmortem tissue, aided by computational methods, to unravel the molecular-genetic underpinnings of neuropsychiatric disorders. Joyce obtained BSc degrees in Biochemistry and in Biotechnology, and an MSc in Neurosciences in the Netherlands. During her dissertation studies, she discovered a mutation in ITPR1 to be causative in SCA15, an ataxic movement disorder. The majority of this work was carried out at the National Institutes of Health (MD, USA), in collaboration with University College London (UK) where she obtained a PhD degree in Neurogenetics. During her subsequent postdoctoral fellowship at the Neural Stem Cell Institute (NY, USA), Joyce developed a resource of temporal gene expression profiles in a human stem cell model of cortical development. After which she applied knowledge gained to study neural development in neuropsychiatric disorders using both stem cell modeling and computational approaches, as an Assistant Project Scientist at UCSD’s Department of Psychiatry (CA, USA). She developed a particular interest in the contribution of astrocytes therein, one she shared with the Gage lab at the Salk Institute (CA, USA) where she was a resident collaborator.