- Selected Publications
Jack Wei, Ph.D., is an Investigator in the Drug Discovery Division of the Lieber Institute. Dr. Wei focuses on the assay development for the screening and studying of mechanisms of action of compounds. Dr. Wei received a B.S. in Biology from Xiamen University, China and a M.S. in Biochemistry from Peking Union Medical College, China. He received his Ph.D. from Emory University, working in the laboratory of Dr. David Pallas on the effect of methylation of Protein Phosphatease 2A. He received his postdoctoral training with Nobel Laureate Robert J. Lefkowitz at Duke University Medical School, where he discovered the independent signal transduction pathways of GPCR mediated b-arrestin and G-protein. His findings led to discovery of biased agonist phenomena. He then moved to the Schering-Plough Research Institute and later on joined Merck Research Laboratories working on a variety of drug discovery projects for cardiovascular and metabolism disorders.
Wei H, Shang J. Wang M, Li Q, Keohane C, Ni W, Chintala M, 2014 Assessing the spontaneous gastrointestinal bleeding risk of antithrombotic agents using Apc min/+ mice. Thromb. Haemost. 111:1121-323.
Noma T, Lemaire A, Naga Prasad SV, Barki-Harrington L, Tilley DG, Chen J, Le Corvoisier P, Violin JD, Wei H, Lefkowitz RJ, Rockman HA. 2007 Beta-arrestin¬mediated beta1-adrenergic receptor transactivation of EGFR confers cardioprotection. J. Clin. Invest. 117:2445-58
Wei H, Ahn S, Barnes, WG, Lefkowitz RJ 2004 Stable interaction between beta -arrestin2 and AT 1A receptor is required for beta -arrestin2 mediated activation of extracellular signal-regulated kinase 1 and 2 J. Biol. Chem. 279:48255-61