The goal of research at LIBD is to identify new strategies to change the lives of individuals affected by schizophrenia and related developmental disorders.
From Genes to Drugs
Rather than focusing on disease specific molecules, our drug development program has identified targets with much broader clinical application, focusing on chemicals involved in “tuning” human cortical function to improve cognition and modulate impulse control across many conditions where these capacities are compromised. Through investigation of these innovative targets, our scientists are validating new approaches that will ultimately lead to novel treatments.
In seven years of operations, we have made considerable progress in identifying and developing a promising set of novel therapeutic targets including two that could be in clinical trials within two to three years. In addition, we have four promising leads that could introduce two new drugs into Phase II clinical trials by 2021.
Our Pipeline
Project
INDICATION(S)
FUNDING SOURCE/PARTNER
Target ID
Target Validation
Hit to Lead
Lead Optimization
Candidate Selection
IND Enabling
Phase I
Phase II
Phase III
Nav1.8
Pain, autism
Latigo Biopharmaceutical
COMT
Schizophrenia
Boehringer-Ingelheim
GABA
Peripheral Hypersensitivity (autism, IBS)
Available
IP6K1
Chronic Kidney Disease,
Obesity
Available
GPCR-Tgt1
Schizophrenia
Blackbird BioVentures+VC
GPCR-Tgt2
Cognition, reward
Available
Ion Channel-Tgt1
Pain, epilepsy
Blackbird BioVentures+VC
Ion Channel-Tgt2
Schizophrenia, epilepsy
Available
Enzyme
Pain
Blackbird Laboratories/JHU
Exploratory DD Initiative
Schizophrenia, others
LIBD
48,000 SQUARE FEET
Our state-of-the-art laboratory space is located on the Johns Hopkins Medical Campus. LIBD is the largest non-Johns Hopkins University employer of the East Baltimore inner-city development project.