• About
  • Selected Publications
About

About

Kristin L. Bigos, Ph.D. is an Investigator in the division of Clinical Pharmacology. Her research uses pharmacogenetics and functional neuroimaging to identify novel drug targets, to test potential therapeutic agents, and to understand the variability in response to psychiatric medications. Dr. Bigos received a B.S. in Premedicine from the Pennsylvania State University and a Ph.D. in Clinical Pharmaceutical Sciences from the University of Pittsburgh. As a graduate student she received the Ruth L. Kirschstein National Research Service Award, and an American Foundation for Pharmaceutical Education Fellowship. She was the 2005 recipient of the Pharmaceutical Sciences Graduate Student Excellence Award given by the University of Pittsburgh School of Pharmacy. Before coming to the Lieber Institute, Dr. Bigos was a post-doctoral fellow in the Clinical Brain Disorders Branch of the Intramural Research Program of the National Institute of Mental Health under Dr. Daniel Weinberger. She was a recipient of the National Institutes of Health Fellows Award for Research Excellence for her research on the functional neuroimaging of glutamate and calcium signaling pathways.

Selected Publications

Selected Publications

Bigos KL, Mattay VS, Callicott JH, Straub RE, Vakkalanka R, Kolachana B, Hyde TM, Lipska BK, Kleinman JE, Weinberger DR. Genetic Variation in CACNA1C Affects Brain Circuitries Related to Mental Illness. Arch Gen Psychiatry. 67(9):939-45, 2010.

Bigos KL, Bies RR, Pollock BG, Lowy JJ, Zhang F, Weinberger DR. Genetic Variation in CYP3A43 Explains Racial Difference in Olanzapine Clearance. Mol Psychiatry. 16:620-625, 2011.

Bigos KL, Pollock BG, Aizenstein HJ, Fisher PM, Bies RR, Hariri AR. Acute 5-HT Reuptake Blockade Poteniates Human Amygdala Reactivity. Neuropsychopharmacology. 33:3221-3225, 2008.

Bigos KL, Pollock BG, Coley KC, Marder SR, Miller DD, Kirshner MA, Bies RR. Sex, Race, and Smoking Impact on Olanzapine Exposure. J Clin Pharmacol. 48(2): 157-165, 2008.

Apud JA, Zhang F, Decot H, Bigos KL, Weinberger DR. Genetic Variation in KCNH2 Associated with Expression in Brain of a Unique Herg Isoform Modulates Treatment Response in Patients with Schizophrenia. Am J Psychiatry. 169:725-734, 2012.