• About Mike
About Mike

About Mike

Mike Poslusney is a medicinal chemist who joined the Drug Discovery Division of the Lieber Institute in October 2013 as a Staff Scientist I. Mike applies his background in medicinal chemistry, and in particular neuroscience, to optimizing lead chemical series for the Division’s multiple programs. Prior to joining the Lieber Institute, Mike worked at the Vanderbilt Center for Neuroscience Drug Discovery, where he focused on designing allosteric modulators of G-protein coupled receptors. His accomplishments there include the discovery of several compounds which directly advanced one project to the lead optimization stage, and led directly to a major industrial collaboration for another project. Previously, Mike worked at Merck, focusing on the COMT inhibitor and siRNA delivery projects. While at Merck, Mike independently designed a safe kilogram scale synthesis of a key intermediate, enabling studies of a leading siRNA delivery conjugate in primates.