Clinical Sciences

Andrew Jaffe

Lead Investigator

Andrew Jaffe, Ph.D., began his postdoctoral work at the Lieber Institute in early 2012. His research focuses on the development and application of statistical models and approaches to high-throughput genomic data, like DNA methylation, gene expression, and sequence variation, in large biological studies. He is particularly interested in “integrative” genomics, which combines multiple types of genomic data on the same individuals to better understand the biological systems in the brains of both “normal” individuals and those affected by neuropsychiatric disorders like schizophrenia, bipolar disorder, and major depression. Dr. Jaffe attended Johns Hopkins University for both his undergraduate (BA – Public Health Studies, 2008) and graduate education (PhD – Epidemiology, MHS – Bioinformatics, 2011). His dissertation work focused on developing statistical methods for analyzing high-throughput epigenetic data in large epidemiological studies.

Selected Publications

Jaffe AE, Gao Y, Deep-Soboslay A, Tao R, Hyde TM, Weinberger DR, Kleinman JE Mapping DNA methylation across development, genotype, and schizophrenia in the human frontal cortex. Nature Neuroscience. 2016 Jan;19(1):40-7.

Ivanov NA, Tao R, Chenoweth JG, Brandtjen A, Mighdoll MI, Genova JD, McKay RD, Jia Y, Weinberger DR, Kleinman JE, Hyde TM, Jaffe AE. Strong Components of Epigenetic Memory in Cultured Human Fibroblasts Related to Site of Origin and Donor Age. PLoS Genet. 2016 Feb 25;12(2):e1005819

Jaffe AE, Shin J, Collado-Torres L, Leek JT, Tao R, Li C, Gao Y, Jia Y, Maher BJ, Hyde TM, Kleinman JE, Weinberger DR. Developmental regulation of human cortex transcription and its clinical relevance at base resolution. Nature Neuroscience. 2015 Jan;18(1):154-61.

Jaffe AE, Irizarry RA. Accounting for cellular heterogeneity is critical in epigenome-wide association studies. Genome Biol. 2014 Feb 4;15(2):R31.

Jaffe AE, Deep-Soboslay A, Tao R, Hauptman DT, Kaye WH, Weinberger DR, Hyde TM, Kleinman JE. Genetic Neuropathology of Obsessive Psychiatric Syndromes. Translational Psychiatry. 2014 Sep 2;4:e432.